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The interplay of cannabinoids and the so-called “Entourage Effect”

Updated: Feb 16, 2023

The entourage effect is a fascinating phenomenon that is present in the cannabis plant and is known to increase the effectiveness of cannabis when all its components are used together.


Essentially, the entourage effect is a synergistic combination of secondary cannabinoids and terpenes in cannabis, which enhance the therapeutic benefits beyond that of simply consuming THC and CBD. This means that the entourage effect is believed to make cannabis as a whole plant medication more powerful than isolated compounds. In other words, the effects become amplified beyond what can be achieved solely with either cannabinoid alone.

The entourage effect is one of the most important factors to consider in cannabinoid therapy, as it can maximize the therapeutic benefits of individual cannabinoids and reduce the amount of THC needed to generate the desired effect.

The entourage effect is thought to work through various mechanisms. First, different phytochemicals may work together to enhance the absorption and utilization of other compounds. In addition, the cannabis plant itself may produce tertiary compounds that have an effect on individual cannabinoids. Lastly, the influence of different terpenoids may alter the way in which cannabinoids interact with the endocannabinoid system, which could affect how the body metabolizes and utilizes cannabinoids.

Overall, the entourage effect is a powerful synergistic combination of secondary cannabinoids and terpenes that can maximize the therapeutic benefits of cannabis. While research on the entourage effect is still in its early stages, there is already some evidence that cannabis has a higher potential when cannabinoids and terpenes are used together. As research continues to uncover the mechanisms behind the entourage effect, it is likely that it will become less of a novelty and more of an expectation in cannabinoid therapy.

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